RAF Typhoon jets have operated alongside French aircraft in a combined operation on an subterranean weapons facility in Syria operated by the Islamic State group (IS), as stated by the British defence ministry.
The location, located using surveillance, was assessed as containing munitions and bombs, the statement said, and was located in mountains just to the north of Palmyra in Syria's central region.
"Our fighter planes used Paveway IV guided bombs to strike a series of approach shafts down to the site... initial indications suggest the strike was effective," the MoD said.
There was no indication of any harm to civilians in the attack late on Saturday and each participating jet returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - also known as Daesh - imposed extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and commitment to stand shoulder to shoulder with our partners, to eliminate any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief John Healey remarked.
British military aircraft have carried out overwatch operations over Syrian airspace to "forestall any attempted resurgence" of the group following its routing at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of our armed forces participating in this strike for their professionalism and their courage," the Defence Secretary said. "They were among a great many UK service members deployed over Christmas and New Year. This action, to take out terrorist threats who threaten our safety, shows how British military are always on standby, throughout the year, keeping Britain secure within its borders and influential overseas."
Last December, the United States armed forces executed what it termed a "large-scale strike" against IS targets in the country, subsequent to an attack killed two US troops and a civilian linguist in the Palmyra area.
The U.N. says Islamic State still has roughly 5-7 thousand fighters in Iraq and Syria.